Candesartan ester used in the treatment of essential hypertension, can be used alone, can also be used with other antihypertensive drug combination. So, candesartan ester piece of mechanism of action is what?

Candesartan ester is a class of heart head blood-vessel blood pressure drugs. Ingredient of candesartan ester, and its chemical name: (+) - 1 - (cyclohexanol oxygen carbonyl oxygen generation) ethyl - [2 - ethoxy - 1 - [[2 - (1 h - four nitrogen imidazolyl - 5) al phenyl - 4] methyl] - 1 h - benzene and imidazole - 7] carboxylic acid ester.

Candesartan ester in the body quickly is hydrolyzed into active metabolite candesartan. Candesartan for angiotensin II AT1 receptor antagonist, by combined with vascular smooth muscle of AT1 receptor antagonist of angiotensin II vasoconstriction, reducing peripheral vascular resistance. Another thought: candesartan can inhibit the adrenal glands secrete aldosterone and play a certain antihypertensive effect.

Experiment shows that: in patients with high blood pressure patients take candesartan ester tablet can cause many times of plasma renin activity and angiotensin Ⅰ concentration and angiotensin Ⅱ concentration increased; This article 2 ~ 8 mg once daily continuous administration, can make the systolic pressure, diastolic pressure drops, left ventricular myocardial weight, peripheral vascular resistance decreased, and the central discharge, ejection fraction, renal vascular resistance, renal blood flow and glomerular filtration rate has no obvious influence; For patients with primary hypertension with cerebrovascular disorders, for had no effect on cerebral blood flow.

Looked at the above introduction, believe everybody already knows candesartan ester mechanism of action, if there is not understand place, can consult candesartan ester manufacturer of professional and technical personnel, must be able to solve your problem. Hope these information can help to you.

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