Use and description: scientific research reagents, which are widely used in molecular biology, pharmacology research aspects. Guangdong candesartan ester in the body quickly be hydrolyzed into active metabolite candesartan, candesartan for selective angiotensin II receptor antagonists (ATl), by combined with vascular smooth muscle ATI receptors antagonist of angiotensin II vasoconstriction, reducing peripheral vascular resistance. Another thought: candesartan can inhibit the adrenal glands secrete aldosterone and play a certain antihypertensive effect. Candesartan not restrain excited peptidase Άς, does not affect the slow shock peptide degradation. Experiment shows that: in patients with high blood pressure patients take this product many times can cause the plasma renin activity and angiotensin I elevated concentration and angiotensin Άς concentration; This product for 2-8 mg once daily, can make the systolic pressure, diastolic pressure drops, left ventricular myocardial weight, peripheral vascular resistance decreased, and the central discharge, ejection fraction, renal vascular resistance, renal blood flow and glomerular filtration rate has no obvious influence; For patients with primary hypertension with cerebrovascular disorders, for had no effect on cerebral blood flow.
The solubility of guangdong candesartan ester, candesartan ester in water solubility, guangdong candesartan ester in the solubility of physiological saline, candesartan ester in the solubility of PBS buffer, candesartan ester in DMSO, solubility in organic solvents such as ethanol, guangdong candesartan ester in the application of cell experiment, guangdong candesartan ester in experimental rats and other animals.
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